Living plant collections play a crucial role in ex situ conservation, but their conservation value hinges on assessment of their composition, data quality and on strategic planning for optimization of the collection that takes into account species diversity, conservation status and allocation of resources.Cactaceae is one of the most threatened pla
Simultaneous Determination of Metamizole, Thiamin and Pyridoxin Using UV-Spectroscopy in Combination with Multivariate Calibration
Purpose: Analysis of drugs in multicomponent system officially is carried out using chromatographic technique, however, this technique is too sex-swings laborious and involving sophisticated instrument.Therefore, UV-VIS spectrophotometry coupled with multivariate calibration of partial least square (PLS) for quantitative analysis of metamizole, thi
DeepSRE: Identification of sterol responsive elements and nuclear transcription factors Y proximity in human DNA by Convolutional Neural Network analysis.
SREBP1 and 2, are cholesterol sensors able to modulate cholesterol-related gene expression responses.SREBPs binding sites are characterized by the presence of multiple target sequences as SRE, NFY and SP1, that can be arranged differently in different genes, so that it is not easy to Storage identify the binding site on the basis of direct DNA sequ
Crystal Structure, Hirshfeld Surface Analysis, In-Silico and Antimycotic Investigations of Methyl 6-methyl-4-(4-nitrophenyl)-2-oxo-1,2-dihydropyrimidine-5-carboxylate
Herein, we report the preparation of methyl 6-methyl-4-(4-nitrophenyl)-2-oxo-1,2-dihydropyrimidine-5-carboxylate 2, obtained by the regioselective oxidative dehydrogenation of the dihydropyrimidine derivative 1 in the presence of cerium ammonium nitrate.The structure of compound 2 was investigated by single-crystal X-ray diffraction (SC-XRD), which
Translating CD47-targeted therapy in gastrointestinal cancers: Insights from preclinical to clinical studies
Summary: This review presents a thorough investigation of the role of CD47 in gastrointestinal cancers.We performed a comprehensive, in-depth review of over 100 preclinical and clinical studies focused on inhibiting CD47.The research highlights the potential of targeted CD47 to enhance existing treatments by Garbage/Recycling Container Lids boostin